Search Results for: Sarcopenia: la prevenzione, il sospetto, la diagnosi e le azioni per il medico di medicina generale

Taglio del nastro per Prevenzione in azione nel centro di Ancona

Introduction
Statins are among the most widely used drugs. While they are effective for primary and secondary prevention of cardiovascular (CV) disease in middle-aged subjects, their benefits for prevention in older adults (aged ≥70 years) without CV disease are uncertain, particularly for those with multimorbidity. Statin side effects and drug interactions are common in older patients and may negatively impact quality of life. To date, the only randomised controlled trial (RCT) investigating statin discontinuation in older adults has demonstrated no difference in survival but did note a small improvement in quality of life for those who discontinued statins. However, this trial exclusively enrolled patients with a life expectancy

Introduction
Sarcopenia and frailty have been identified as negative predictors of health outcomes. Patients with stroke, traumatic brain injury (TBI), knee osteoarthritis (OA) and breast cancer commonly experience low physical activity levels in the chronic phase of recovery. This prospective study aims to explore the feasibility of multimodal screening and longitudinal tracking of various biomarkers from the acute to chronic phase of disease to determine the relationship with frailty outcomes.

Methods and analysis
A prospective longitudinal observational cohort study involving Asian populations is planned over 3 years. Enrolled participants with index conditions of acute stroke, TBI, knee OA and breast cancer will be recruited from rehabilitation hospitals and clinics and followed longitudinally. Reference thresholds from the Asian Working Group on Sarcopenia will be used. Variables include self-reported questionnaires, disease and comorbidity characteristics, anthropometric measurements, appetite questionnaires, muscle ultrasound (MUS), muscle/bone mass, blood biomarkers and markerless gait motion systems. In particular, physical performance (short physical performance battery and hand grip strength), sarcopenia (SARC-F questionnaire) and frailty assessment (FRAIL score, clinical frailty scale), four-region MUS, body composition analysis, dual X-ray absorptiometry, bone mineral densitometry, physical activity levels (International Physical Activity Questionnaire for the elderly [IPAQ-E], fitness trackers) and health-related quality of life assessment (EuroQoL-5D questionnaire five level [EQ5D-5L]) will be used. Blood biomarkers measuring metabolic health (eg, glycated haemoglobin, cholesterol, fasting glucose and 25-OH vitamin D) and inflammation (eg, Tumor Necrosis Factor-alpha [TNF-α] and Monocyte Chemoattractant Protein-1 [MCP-1]) will be measured at baseline. Data collection will take place at postrecruitment baseline (hospital admission), 1, 6 months, 12 months and 2 years postrecruitment (inpatient) and at postrecruitment baseline, 6 months, 12 months and 2 years postrecruitment (outpatient).

Ethics and dissemination
Ethical approval has been obtained from the National Healthcare Group Domain Specific Review Board (2023/00105). Findings will be disseminated through conference presentations and publication in scientific journals.

Trial registeration number
NCT06073106.

Benefici anche con 2,5-5 ore di camminata veloce a settimana

Benefici anche con 2,5-5 ore di camminata veloce a settimana

Appuntamento sabato e domenica, porte aperte alla prevenzione

Appuntamento sabato e domenica, porte aperte alla prevenzione

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Introduction
The rapidly expanding population of ageing and older adults with disability has been a continuing public health priority in recent decades. The first step towards solving this issue is to assess disability accurately and identify high-risk factors and individuals for early prevention. We aim to establish a prospective cohort, the Beijing Longitudinal Disability Survey in Community Elderly (BLINDSCE), using multidimensional disability assessments and to develop multifactorial models for disability prediction among community-dwelling older adults.

Methods and analysis
The BLINDSCE is a prospective cohort study that includes community-dwelling older adults aged ≥65 years with or without disability from urban and rural areas in Beijing. Participants complete structured questionnaires and undergo assessments of disability, cognition and disability-related factors and outcomes. Disability is assessed using the WHO’s Disability Assessment Schedule 2.0, activities of daily living, the Barthel index, locomotor function and physical function. Based on baseline cross-sectional information, the relationships between multiple factors and disability can be initially screened using logistic regression. Every 1–1.5 years, participants will receive a follow-up survey to remeasure disability, cognitive function and other disability-related factors and outcomes. At least three follow-ups are scheduled. The primary outcome of this study is disability. The secondary outcomes include cognition and many disability-related conditions, such as falls, pain, poor health, decreased intrinsic capacity, frailty, sarcopenia, hospitalisation and death. Cox proportional hazards or logistic regression will be used to analyse follow-up data and construct prediction models, which will be validated internally and externally.

Ethics and dissemination
The Ethics Committee of Xuanwu Hospital, Capital Medical University, approved this study (No: [2023]129). The results will be published in peer-reviewed journals focusing on geriatric medicine and presented at related scientific conferences.

Trials registration number
NCT06863727. Stage of study: recruiting.

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