Search Results for: Gestione dei sintomi del tratto urinario inferiore femminili (LUTS - Lower Urinary Tract Symptoms)

Uno studio retrospettivo multicentrico condotto da un gruppo di ricercatori italiani — sotto la direzione di Calogera Butera dell’Unità di Neurofisiologia, IRCCS Istituto Scientifico San Raffaele, Milano — e pubblicato su NeuroRehabilitation, ha evidenziato che la maggior parte dei pazienti con sclerosi multipla trattati con tossina botulinica di tipo A (BoNT-A) per la gestione della spasticità focale riferiva soddisfazione clinica nel corso di diversi cicli di trattamento. 

Al congresso EuroPCR 2025 di Parigi, e pubblicati contemporaneamente sul “Journal of the American College of Cardiology”, sono stati presentati i dati aggiornati a dieci anni dello studio DANAMI-3-PRIMULTI, che ha valutato l’efficacia a lungo termine della rivascolarizzazione completa rispetto al trattamento della sola arteria infartuata nei pazienti con infarto miocardico con sopraslivellamento del tratto ST (STEMI) e coronaropatia multivasale.

The purpose of this American Gastroenterological Association (AGA) Institute Clinical Practice Update (CPU) is to summarize the available evidence and offer expert best practice advice on the incorporation of the functional lumen imaging probe (FLIP) into clinical practice, specifically its utility in the evaluation of esophageal symptoms, esophageal motor dysfunction, gastroesophageal reflux disease, and eosinophilic esophagitis.

In a large observational study, risk for cardiovascular disease was 25% lower among vaccinated people.

In our cohort, scheduled caesarean section between 39+0–39+6 weeks for large infants at birth was associated with lower odds of severe adverse maternal outcomes, severe neonatal neurological morbidity, and other severe neonatal morbidity compared to induction of labor at 38+0–38+6 weeks. For women that underwent induction of labor, the odds of emergency caesarean section were lowest at 39+0–39+6 weeks. Infants with birthweight >97th centile for gestational age had the highest risk of adverse outcomes regardless of gestation or method of planned birth.

Circulation, Ahead of Print. BACKGROUND:Neurodevelopmental and functional impairments are among the most consequential morbidities for survivors of hypoplastic left heart syndrome after staged single ventricle surgical palliation. The SVRIII trial (Long-Term Outcomes of Children With Hypoplastic Left Heart Syndrome and the Impact of Norwood Shunt Type) enrolled adolescents, who were randomized to different surgical shunt types at the time of Norwood procedure as neonates, for multifaceted in-person evaluation. This study reports their neurodevelopmental outcomes.METHODS:Transplant-free survivors from SVRIII were invited to complete an in-person comprehensive neurodevelopmental evaluation in early adolescence. Outcomes across domains of cognition, academics, learning, memory, and attention, as well as social, emotional, behavioral, adaptive, and executive function, were compared with those of normative populations. Associations with demographic and medical covariates, including Norwood shunt type, were also assessed.RESULTS:Among 549 participants enrolled in the SVR trial (Single Ventricle Reconstruction), 200 of the 237 SVRIII participants (84%) completed a neurodevelopmental evaluation at a mean age of 11 years (range, 10 to 14 years). SVRIII participants who did versus did not undergo evaluation were more likely to be male (63% versus 51%), to be White (87% versus 76%), and to have a higher Childhood Opportunity Index score (61±26 versus 46±39). Full-scale intelligence quotient (88±18) was significantly lower than in the normative population, with 39% >1 and 15% >2 SD below the normative mean. Similar patterns were seen for reading (38% >1 SD and 16% >2 SD below the normative mean) and math (38% >1 SD and 19% >2 SD below the normative mean) scores. Attention, executive functioning, social development, visual memory, and adaptive functioning were all more impaired than in the normative population. Measures of socioeconomic status, number of medical complications, and requirement for a gastrostomy tube were each independent predictors of neurodevelopment, with socioeconomic status the most consistently significant factor across models. Group differences by shunt type were inconsistent across neurodevelopmental domains without a clear benefit of one surgical strategy.CONCLUSIONS:In early adolescence, transplant-free survivors of surgical palliation for hypoplastic left heart syndrome show concerning impairments across all domains of neurodevelopment. The distribution of affected outcomes is broad and associated with demographic, medical, and, most frequently, socioeconomic factors. Our findings support recommendations for neurodevelopmental evaluation during adolescence to guide individualized interventions to promote educational success and psychosocial well-being.REGISTRATION:URL:https://www.clinicaltrials.gov; Unique identifier: NCT02455531.

Uno studio pubblicato su “JAMA Psychiatry” ha analizzato la comparsa e l’intensità dei sintomi da sospensione degli antidepressivi, sollevando dubbi sulla necessità di strategie di riduzione graduale di lunga durata. 

In this cross-sectional study, high intake of carbohydrates was associated with higher MRI-detected vascular brain injury and lower cognitive scores, whereas higher intakes of total and individual types of fats were associated with lower vascular brain injury and higher cognitive scores.

Uno studio prospettico pubblicato su Pain and Therapy condotto presso il centro regionale per le cure palliative dell’Ospedale La Maddalena di Palermo ha analizzato, a distanza di 12 anni da una precedente indagine, le strategie di prescrizione degli oppioidi e l’efficacia analgesica in pazienti ricoverati in un’Unità di Cure Palliative Acute (APCU). I risultati mostrano che un approccio intensivo e personalizzato consente un controllo efficace del dolore senza necessità di aumentare l’equivalente in morfina orale (OME), e sottolineano l’importanza di una gestione esperta nella terapia del dolore oncologico.

La fibromialgia (FM) è una condizione cronica e debilitante, ancora priva di un trattamento farmacologico risolutivo. In questo scenario, il Gruppo di Interesse Speciale sul Dolore Neuropatico della Società Italiana di Neurologia ha condotto una revisione narrativa degli RCT più recenti, formulando un consenso su strategie farmacologiche e non farmacologiche per la gestione della FM. Il documento fornisce indicazioni pratiche per neurologi e clinici, basate sull’evidenza disponibile e sull’esperienza specialistica.

Due nuovi studi presentati a Roma durante il XIVesimo International Congress of Dermatology confermano il valore del deucravacitinib nel trattamento della psoriasi a placche da moderata a severa: da un lato l’efficacia reale su sintomi, qualità di vita e clearance cutanea, dall’altro il suo profilo di tollerabilità anche in pazienti con molteplici comorbidità e farmaci concomitanti.

Su iniziativa della Senatrice Elisa Pirro, Presidente dell’Intergruppo parlamentare per la Donazione e il trapianto di organi, tessuti e cellule, è stato presentato oggi il documento di indirizzo “La GvHD cronica: dalla conoscenza alla gestione del paziente”.

Colpisce il 20-50% degli operati. Proposta giornata nazionale

In Reply We appreciate the thoughtful letter from Drs Zhang and Wang regarding the publication of the main results of our IN-PEACE trial of palliative care integrated into dementia care management, including excellent questions and suggestions, as well as highlighting the finding of reducing ED visits and hospitalizations by half. We agree with several suggestions made by the authors for future interventions, such as a stepped-care approach to provide greater resources to vulnerable or underserved populations, patients with more severe symptoms, and caregivers with higher levels of depression or distress.