Prevalence and predictors of permanent pacemaker implantation in patients with aortic stenosis undergoing transcatheter aortic valve implantation: a prospective cohort study

Objectives
The primary objectives were to identify the predictors of new permanent pacemaker implantation in patients with aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI). The secondary objectives were to investigate the temporal changes in permanent pacemaker implantation following TAVI and its impact on long-term prognosis.

Design
Prospective observational cohort study of patients with AS undergoing TAVI.

Setting
Single-centre study conducted at a tertiary hospital in Western Norway between 2012 and 2019.

Participants
Among 600 consecutive patients with severe AS who were treated with TAVI, 52 patients with permanent pacemaker prior to TAVI were excluded. The remaining 548 patients were included in the present study.

Baseline measures
An evaluation of baseline risk factors, 12-lead ECG and echocardiography.

Primary outcome measures
The need for a new pacemaker implantation ≤30 days following TAVI and all-cause death.

Results
The mean age was 80.6±6.7 years, and 50% were males. Among the 548 eligible patients, 173 (31.6%) underwent pacemaker implantation ≤30 days following TAVI, evenly distributed between females and males (29.6% vs 33.6%, p=0.317), with higher implant rates at low-volume phase (2012–2015) and lower implant rates at high-volume phase (2016–2019) (45.8% vs 23.9%, p

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Febbraio 2025