Autore/Fonte: Mayo Clinic
Identificata una nuova immunoterapia mirata per il cancro ovarico
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24 Aprile 2025
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Autore/Fonte: Mayo Clinic
Autore/Fonte: Università di Umea in Svezia
Autore/Fonte: Journal of Clinical Oncology
Nursing Up, per operatori salute rischio tumori del 10% in più
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Una nuova ricerca condotta dall’Oregon Health & Science University ha […]
Al Santa Croce di Fano impiantato dispositivo con successo
Background
Inflammation is indicated as one of the factors that play a role in the development of schizophrenia, with several studies having found considerable inconsistencies in their results. Few have investigated the role of inflammation in primary psychosis in blood and cerebrospinal fluids simultaneously, the aim of this study being to investigate the expression of blood and cerebrospinal fluid inflammatory cytokines in treatment-naive first-episode psychotic participants.
Methods and analysis
This is a combined cross-sectional and prospective observational study, which is currently taking place in Durban, South Africa, will recruit 60 participants (30 cases and 30 matched controls). The primary objective is to describe baseline CSF and longitudinal expression/levels of inflammatory cytokines in the blood in persons diagnosed with first-episode psychosis (FEP) for 12 months. The secondary objective is to describe the associations between inflammatory cytokines and psychosis severity, neurocognitive performance, antipsychotic response and metabolic changes at different time points (baseline, 3, 6 and 12 months).
Interventions
We will collect the sociodemographic details of all participants, and the Positive and Negative Symptoms Scale, Patient Health Questionnaire-9, Childhood Trauma Scale, Repeatable Battery for the Assessment of Neuropsychological Status Update, metabolic markers and inflammatory markers (venous blood and lumbar puncture cerebrospinal fluid) for those with FEP. Data from matched controls will only be collected at one point and no follow-ups (cross-sectional).
Ethics and dissemination
The study protocol has been approved by the University of KwaZulu-Natal Biomedical Research Ethics Committee (BREC/00004714/2022). The study is nested in an ongoing study titled the burden of HIV and Psychosis in an African setting: a longitudinal study of HIV-infected and non-infected patients with First-Episode Psychosis (BREC 571/18). The results will be actively disseminated through peer-reviewed journal publications and conference presentations.
A Rivoli e Pinerolo, nel Torinese, le prime tre operazioni
Trattamento rapido e tollerato con ridotto impatto estetico
Trattamento rapido e tollerato con ridotto impatto estetico
Autore/Fonte: Mayo Clinic Proceedings
All’Irccs Negrar per la radioterapia, tecnologia unica in Italia
Studio, una bevanda al giorno aumenta il rischio di 5 volte