Risultati per: Trattamento domiciliare di un paziente positivo al virus SARS-Cov-2

Circulation, Ahead of Print. The postacute sequelae of SARS-CoV-2, also known as Long COVID, may affect 10% to 25% of individuals diagnosed with SARS-CoV-2. More than 100 symptoms have been reported among patients with Long COVID, but almost all patients report severe fatigue, orthostatic intolerance, shortness of breath, and reductions in exercise tolerance. Emerging data suggest that cardiovascular deconditioning plays a major role in the development of this syndrome and that reductions in functional capacity among patients with Long COVID are comparable to reductions seen among individuals with cardiovascular deconditioning resulting from bed rest. Concern has been raised about the use of exercise training as part of the management strategy for patients with Long COVID. However, exercise training appropriately tailored to the patient with cardiovascular deconditioning may be an effective strategy to facilitate improvement in symptoms. This American Heart Association scientific statement provides a concise yet comprehensive overview of mechanisms contributing to development of Long COVID and methods by which exercise training may be applied to this unique patient population to alleviate symptoms and improve quality of life. In addition, methods of reintroducing exercise and return to play among athletes affected by COVID-19 are discussed.

Per la fase avanzata. Al San Carlo di Potenza

Confermato virus epatite D, Citomegalovirus sotto osservazione

Studio dell’Istituto nazionale tumori su terapia non chirurgica

Studio dell’Istituto nazionale tumori su terapia non chirurgica

Riparte campagna Novartis contro il rischio cardiovascolare

New England Journal of Medicine, Volume 392, Issue 23, Page 2385-2387, June 19, 2025.

Objectives
Investigate determinants of post-COVID-19 condition (PCC) clinic attendance among participants not hospitalised versus hospitalised during the SARS-CoV-2 infection.

Design
Retrospective cohort study.

Setting
Six population-based registers with high coverage to cover all adults residing in Stockholm County, Sweden.

Participants
Adults residing in Stockholm County on 31 January 2020, with a SARS-CoV-2 infection through 30 November 2022, who did not die or move out of Stockholm County within 90 days.

Primary outcome measures
PCC clinic attendance from 90 days after the SARS-CoV-2 test until date of death, date of moving out, or 30 November 30,2023.

Results
Of non-hospitalised and hospitalised participants, 737 of 464 674 (0.2%) and 433 of 23 374 (1.9%), respectively, attended a PCC clinic. A total of 75 878 (16.3%) of non-hospitalised participants and 6190 (26.5%) of hospitalised participants presented with new-onset symptoms that could indicate PCC in primary care. The strongest determinants of attendance among non-hospitalised participants were mental health disorder (adjusted risk ratio (aRR) 2.57, 95% CI 2.21 to 2.98), asthma (2.39, 1.97–2.92) and >4 PCC symptoms in 2019 (2.27, 1.60–3.24), and among hospitalised participants were >31 sick days in 2019 (1.94, 1.47–2.56), 1–30 sick days in 2019 (1.56, 1.06–2.29) and obesity (1.51, 1.19–1.93). The most common clinical presentation was fatigue (n=526, 71.4%) among non-hospitalised and dyspnoea (n=148, 34.2%) among hospitalised participants.

Conclusions
PCC clinic attendance characteristics differed between non-hospitalised and hospitalised participants. Distinguishing PCC from conditions with overlapping symptoms and determining the appropriate level of care may be challenging, with risk of resource displacement effects and inappropriate care.

Innovations introduced by this analysis include non-parametric modelling of the exposure-response relationship between RSV activity and hospitalizations and evaluating the predictive reliability of two RSV proxies. Our findings highlight the substantial adult RSV disease burden, provide estimates for countries with no prior data (particularly those in (sub)tropical climates such as Mexico and Brazil), and illustrate the considerable geographic variability in adult RSV incidence. These results can guide future research, interventions, and policy decisions, including those involving adult RSV vaccines.

Giustetto: “Senza inversione rotta salute sempre più mercato”

All’ospedale di Città Castello espiantati fegato, reni e cornee

Primo impianto ‘Carmat’ in un ospedale pubblico in Veneto

Primo impianto ‘Carmat’ in un ospedale pubblico in Veneto

To the Editor The Research Letter by Dr Karaba and colleagues, “Antibody Response to Respiratory Syncytial Virus Vaccination in Immunocompromised Persons,” provides interesting real-world data on the effectiveness of the respiratory syncytial virus (RSV) vaccine in patients with self-reported immunocompromising conditions from a prospective national cohort. The heterogeneity and low immunogenicity response to the vaccine are noteworthy, as 40% of patients did not achieve seroconversion or reach the predefined threshold of neutralizing antibodies. This finding differs from the high overall efficacy that has been described among older adults in the general population (72%-94% and 62%-85.7%, respectively, in 2 studies evaluating prefusion F vaccines).

In Reply We appreciate the summary and recognition by Dr Vicente-Rabaneda and colleagues of our recent article detailing the first published data on RSV antibody response in immunosuppressed persons. As noted, this prospective cohort study largely comprised solid organ transplant recipients with severe RSV disease burden owing to age, multimorbidity, and immunosuppression; the study included a minority of participants (18%) with an immune-mediated inflammatory condition.

Objectives
SARS-CoV-2 infections in young children are predominantly transmitted through family clusters and typically present with mild symptoms. Most affected children receive healthcare at home or within community healthcare centres. Previous studies from China on the clinical features of infected children have mostly focused on hospitalised cases. In this study, we aimed to investigate the clinical characteristics of these infected children aged 0–6 years old in the community during the Omicron wave in Beijing.

Design
In this community-based survey, we recruited the families with young children aged 0–6 years. Data from these children were reported by their caregivers. Collected data included demographics, family cluster features, symptom burden, breastfeeding practices, immunisation status and treatments received. We analysed the prevalence of symptoms across different age groups and compared clinical features between vaccinated and unvaccinated children aged over 3 years.

Setting
The community survey was conducted in the Qingta community of Beijing from 7 January to 22 January 2023.

Participants
Participants were a subsample of the Family Nurturance Practices Cohort Study (Qingta community, Beijing, n=2521). Totally, 1492 children aged 0–6 years were reported by their caregivers, and 1464 of these children were included in this study.

Results
In the study, 145 infants (9.9%), 407 toddlers (27.8%) and 912 preschoolers (62.3%) were included, respectively. Compared with preschoolers, more infants and toddlers presented with high-grade fever, gastrointestinal manifestations (diarrhoea or constipation, loss of appetite and vomiting), rash, fatigue, irritability and sleeping problems (p