Risultati per: Le cause della polmonite nei bambini

Stroke, Volume 55, Issue Suppl_1, Page AWMP67-AWMP67, February 1, 2024. Introduction:A major cause of cerebral microbleeds (CMBs) is underrecognized and has been attributed to cerebral amyloid angiopathy (CAA) throughout modern medicine. CMBs are acquired by patients undergoing cardiopulmonary bypass (CPB). CPB is utilized for heart and lung transplants, aorta repairs, valve surgeries, mass resections, and coronary artery bypass grafting (CABG) which alone accounts for 400k patients per year. CABGs can be done off CPB in certain patients. Due to their distribution, these CMBs are attributed to CAA, leading to confounding research and suboptimal patient care, especially in those requiring anticoagulation.Methods:This was a single-center, IRB approved, retrospective cohort study of patients who underwent CPB and had postop MRI between 11/1/11 and 3/1/23. Preop and additional postop MRIs were analyzed if available. Outcomes included number and distribution of CMBs, presence of superficial siderosis, FAZEKAS, and CPB duration. We also analyzed MRIs of patients who had off CPB CABG during the same period.Results:Out of 60 patients who underwent CPB, 60 had predominantly cortical CMBs on postop MRI, with a mean of 50 CMBs, and mean age of 61. The 6 patients who had CABG off CPB had 0 CMBs. Higher CMBs were associated with longer CPB duration and with procedures that are associated with more blood loss (p< 0.05). Despite having CMBs, no CPB patients had superficial siderosis, and they had relatively low FAZEKAS scores. Nineteen of the CPB patients had future MRIs and had no evidence of CMB progression.Conclusion:Cortical CMBs are associated with procedures that use CPB and are not seen in off CPB CABG. The CMBs may be related to utilization of cardiotomy suction that exclusively uses roller pumps. CBP related CMBs are a unique clinical entity that is not associated with the progressive cognitive changes and bleeding risk of CAA. While no significant short-term changes are noted, their mechanism and natural history requires further investigation.

Stroke, Volume 55, Issue Suppl_1, Page ATP120-ATP120, February 1, 2024. Background:Racial disparities in stroke prevalence and outcomes have been well documented in previous studies, but there is not sufficient data based on post-menopausal women. In this study, we aim to analyze stroke hospitalization rates and subsequent mortality rates by race among females aged 55 years and older. We also sought to identify independent predictors of mortality based on race.Methods:We queried the 2019 National Inpatient Sample to identify stroke hospitalizations in women aged >55 years by using ICD-10 CM codes. Demographics were analyzed after stratifying the population by race. Multivariable regression analysis was performed taking stroke admission rates and mortality by race as a primary outcome of interest and the co-primary outcome was independent predictors of mortality by race.Results:A total of 140,805 patients with a median age of 76 [67-85] were included in the study of which 66.9% were white, 16.5% black, 7.5% Hispanic, 3.6% Asian/Pacific Islander 0.6% Native Americans, and 2.5% in the other race category. Blacks (52.8%) and Native Americans (47.9%) were significantly present in the lowest national household income quartile compared to Asians/Pacific Islanders (26.1%). COPD (OR: 1.19 95%, p- 0.017), cancer (OR: 1.27 p – 0.030), and age at admission (OR: 1.02 p

Comunicato del 29/01/2024 n°5

Il dolore addominale comune è la prima causa di assenza da scuola

Al Bambino Gesù, al Meyer e al Gaslini. Non sono ancora note le loro condizioni

Dolore addominale comune è la prima causa di assenza da scuola

Sanitari per Gaza: ‘Bene sia stato accolto nostro suggerimento’

Objectives
COVID-19 infection increased nephrology-related risks and mortality rate among end-stage renal disease (ESRD) patients. The pandemic also disrupted essential healthcare services. We aim to explore all-cause excess mortality among ESRD patients who were members of the Universal Coverage Scheme (UCS), the largest public health insurance scheme in Thailand covering citizens who are not employed in the formal sector, including children and older persons.

Design
A cross-sectional study.

Setting
We retrieved the dataset from the UCS claims database—electronic health records used for processing healthcare expense claims from medical facilities of all UCS members. This database links mortality outcome to civil registration. We employed the WHO’s excess mortality methodology using pre-pandemic data to estimate expected deaths during the pandemic period (March 2020 to August 2022).

Participants
This study included ESRD patients from across Thailand, covered by the UCS.

Primary outcome measure
Excess deaths are the difference between predicted and reported deaths.

Results
Over a 30-month period of the pandemic, the total number of all-cause excess deaths among ESRD patients was 4966 (male 1284; female 3682). The excess death per 100 000 ESRD patients was 3601 (male 2012; female 4969). The relative excess death was 5.7% of expected deaths (95% CI 1.7%, 10.0%). The excess deaths were highly concentrated among patients aged 65 and older.

Conclusion
ESRD patients are significantly more vulnerable to pandemic-related mortality than the general population. Health systems’ capacity to contain the pandemic at varying virulence and maintain essential health services for ESRD patients might be related to the size of excess deaths at different periods. The observed excess deaths highlight the importance of established strategies to reduce all-cause mortality such as rapid vaccine rollout for ESRD patients and sustaining dialysis and other essential services for older patients and other high-risk groups.

Transfer RNA (tRNA) modifications occur through the action of specific enzymes that recognize and modify the nucleotides within the tRNA molecule. Queuine tRNA-ribosyltransferase catalytic subunit 1 (QTRT1) and QTRT 2 co-localize in mitochondria and form a heterodimeric TGT participating in tRNA Queuosine (tRNA-Q) modification. Our previous study demonstrated that Q-tRNA modification plays a novel role in regulating barrier functions of intestinal epithelial cells. However, the roles of tRNA-Q modifications in the maintenance of intestinal mitochondrial homeostasis and the progression of inflammatory bowel disease (IBD) are still unclear.

Risks for both outcomes were greatest in the first year but persisted long after.

Amb. Franchetti Pardo consegna i testi scritti in ucraino

Aumenta il rischio futuro di pressione alta, obesità e diabete

Although the overall age-adjusted US mortality rates related to endocarditis—an infection of the heart valves—declined between 1999 and 2020, the rates rose by about 5% among adults aged 25 to 34 years and by 2% among those aged 35 to 44 years, according to a new study that analyzed death certificate data from the US Centers for Disease Control and Prevention.

Atteso un ulteriore aumento dei casi con riapertura delle scuole