Risultati per: Le cause della polmonite nei bambini

Gruppo specialisti di Padova segue bambini maltrattati

This cohort study evaluates the association between bilateral oophorectomy and all-cause mortality among women with BRCA1 or BRCA2 sequence variations.

Objective
The association between haemoglobin-to-red blood cell distribution width ratio (HRR) and all-cause mortality remains poorly understood. This study aimed to examine the influence of HRR at the time of admission mortality over 1 year and 30 days in patients with sepsis.

Design
This was a secondary analysis.

Setting
This study was conducted in intensive care units (ICUs).

Participants
Adult patients with sepsis were identified and included from an intensive care database based on eligibility criteria.

Primary outcome and measure
The primary outcome was the rate of death within 1 year. The secondary outcome was the death rate within 30 days.

Results
A total of 4233 patients with sepsis who met the inclusion criteria were analysed, excluding those ineligible. These participants were divided into quartiles based on their HRR at admission. The overall mortality rates at 1 year and 30 days were 42.9% and 25.5%, respectively. A significant inverse association was observed between HRR quartiles and all-cause mortality (p

La principessa Kate ha atteso. Gli esperti, c’è un momento giusto

Objective
To identify and synthesise relevant existing prognostic factors (PF) and prediction models (PM) for hospitalisation and all-cause mortality within 90 days in primary care patients with acute lower respiratory tract infections (LRTI).

Design
Systematic review.

Methods
Systematic searches of MEDLINE, Embase and the Cochrane Library were performed. All PF and PM studies on the risk of hospitalisation or all-cause mortality within 90 days in adult primary care LRTI patients were included. The risk of bias was assessed using the Quality in Prognostic Studies tool and Prediction Model Risk Of Bias Assessment Tool tools for PF and PM studies, respectively. The results of included PF and PM studies were descriptively summarised.

Results
Of 2799 unique records identified, 16 were included: 9 PF studies, 6 PM studies and 1 combination of both. The risk of bias was judged high for all studies, mainly due to limitations in the analysis domain. Based on reported multivariable associations in PF studies, increasing age, sex, current smoking, diabetes, a history of stroke, cancer or heart failure, previous hospitalisation, influenza vaccination (negative association), current use of systemic corticosteroids, recent antibiotic use, respiratory rate ≥25/min and diagnosis of pneumonia were identified as most promising candidate predictors. One newly developed PM was externally validated (c statistic 0.74, 95% CI 0.71 to 0.78) whereas the previously hospital-derived CRB-65 was externally validated in primary care in five studies (c statistic ranging from 0.72 (95% CI 0.63 to 0.81) to 0.79 (95% CI 0.65 to 0.92)). None of the PM studies reported measures of model calibration.

Conclusions
Implementation of existing models for individualised risk prediction of 90-day hospitalisation or mortality in primary care LRTI patients in everyday practice is hampered by incomplete assessment of model performance. The identified candidate predictors provide useful information for clinicians and warrant consideration when developing or updating PMs using state-of-the-art development and validation techniques.

PROSPERO registration number
CRD42022341233.

Annals of Internal Medicine, Volume 177, Issue 3, Page 407, March 2024.

Annals of Internal Medicine, Volume 177, Issue 3, Page 407, March 2024.

Inaugurata all’ospedale di Udine per il recupero dei pazienti

Evidence shows that e-cigarette use is associated with wheezing, dyspnea, and bronchitis.

Annals of Internal Medicine, Ahead of Print.

Annals of Internal Medicine, Ahead of Print.

This Swedish nationwide cohort study investigates all-cause and cause-specific mortality among a large cohort of individuals with hypochondriasis and a demographically matched cohort of individuals without hypochondriasis.

Nato in Italia e basato sul genoma, nel mirino il neuroblastoma

Previous research on the mortality risk of people with obsessive-compulsive disorder (OCD) has shown mixed results and hasn’t gone into specific causes of death. Now, results from a large cohort study published in The BMJ suggests they have an 82% higher risk of dying from all causes.

I consigli della Società italiana di pediatria