Risultati per: Le cause della polmonite nei bambini

Dolore addominale comune è la prima causa di assenza da scuola

Sanitari per Gaza: ‘Bene sia stato accolto nostro suggerimento’

Objectives
COVID-19 infection increased nephrology-related risks and mortality rate among end-stage renal disease (ESRD) patients. The pandemic also disrupted essential healthcare services. We aim to explore all-cause excess mortality among ESRD patients who were members of the Universal Coverage Scheme (UCS), the largest public health insurance scheme in Thailand covering citizens who are not employed in the formal sector, including children and older persons.

Design
A cross-sectional study.

Setting
We retrieved the dataset from the UCS claims database—electronic health records used for processing healthcare expense claims from medical facilities of all UCS members. This database links mortality outcome to civil registration. We employed the WHO’s excess mortality methodology using pre-pandemic data to estimate expected deaths during the pandemic period (March 2020 to August 2022).

Participants
This study included ESRD patients from across Thailand, covered by the UCS.

Primary outcome measure
Excess deaths are the difference between predicted and reported deaths.

Results
Over a 30-month period of the pandemic, the total number of all-cause excess deaths among ESRD patients was 4966 (male 1284; female 3682). The excess death per 100 000 ESRD patients was 3601 (male 2012; female 4969). The relative excess death was 5.7% of expected deaths (95% CI 1.7%, 10.0%). The excess deaths were highly concentrated among patients aged 65 and older.

Conclusion
ESRD patients are significantly more vulnerable to pandemic-related mortality than the general population. Health systems’ capacity to contain the pandemic at varying virulence and maintain essential health services for ESRD patients might be related to the size of excess deaths at different periods. The observed excess deaths highlight the importance of established strategies to reduce all-cause mortality such as rapid vaccine rollout for ESRD patients and sustaining dialysis and other essential services for older patients and other high-risk groups.

Transfer RNA (tRNA) modifications occur through the action of specific enzymes that recognize and modify the nucleotides within the tRNA molecule. Queuine tRNA-ribosyltransferase catalytic subunit 1 (QTRT1) and QTRT 2 co-localize in mitochondria and form a heterodimeric TGT participating in tRNA Queuosine (tRNA-Q) modification. Our previous study demonstrated that Q-tRNA modification plays a novel role in regulating barrier functions of intestinal epithelial cells. However, the roles of tRNA-Q modifications in the maintenance of intestinal mitochondrial homeostasis and the progression of inflammatory bowel disease (IBD) are still unclear.

Risks for both outcomes were greatest in the first year but persisted long after.

Amb. Franchetti Pardo consegna i testi scritti in ucraino

Aumenta il rischio futuro di pressione alta, obesità e diabete

Although the overall age-adjusted US mortality rates related to endocarditis—an infection of the heart valves—declined between 1999 and 2020, the rates rose by about 5% among adults aged 25 to 34 years and by 2% among those aged 35 to 44 years, according to a new study that analyzed death certificate data from the US Centers for Disease Control and Prevention.

Atteso un ulteriore aumento dei casi con riapertura delle scuole

Infanzia periodo decisivo per la salute delle ossa

I pediatri: “Pronto Soccorso pieni, più colpiti gli under 5”

Aims
To describe all-cause and cause-specific mortality and to investigate factors associated with mortality among individuals imprisoned for driving under the influence (DUI) of alcohol and psychoactive drugs in the Norwegian prison population.

Design
Retrospective cohort study. The Norwegian prison registry was linked to the Norwegian Cause of Death Registry (2000–2016).

Setting
Norway.

Participants/cases
The cohort consisted of 96 856 individuals imprisoned in Norway over a 17-year period obtained from the Norwegian prison registry.

Primary and secondary outcome measures
Adjusted ORs (aOR) with 95% CI were calculated for death due to any, natural and unnatural causes of death. Analyses were stratified according to DUI convictions: no DUI convictions, only DUI convictions (DUI only), DUI and at least one other drug and alcohol conviction (DUI drug), and DUI and at least one conviction other than drug and alcohol conviction (DUI other).

Results
In total, 29.3% individuals had one or more imprisonments for DUI. The risk of all-cause mortality was elevated for those convicted for DUI, but only in combination with other types of crimes (DUI drug: aOR=1.5, 95% CI 1.4 to 1.6, DUI other: aOR=1.2, 95% CI 1.1 to 1.4). The risk of death from natural causes was significantly elevated for DUI drug (aOR: 1.8, 95% CI 1.6 to 2.0) and for DUI other (aOR=1.3, 95% CI 1.1 to 1.6). The risk of death from unnatural causes was lower for DUI only (aOR=0.8, 95% CI 0.7 to 0.9) and elevated for DUI drug (aOR=1.5, 95% CI 1.3 to 1.6).

Conclusions
The risk of all-cause mortality was significantly elevated for those convicted of DUI, but only in combination with other types of crimes.

Circulation, Volume 148, Issue 25, Page 2069-2071, December 19, 2023.