Circulation, Volume 148, Issue Suppl_1, Page A15486-A15486, November 6, 2023. Introduction:Many governing bodies and major international societies recommend against heart transplantation (HTx) in patients with severe cognitive-behavioral disabilities, however no clear criteria are offered to define severity. Patients with Autism Spectrum Disorders (ASD) may face systematic discrimination when being evaluated for HTx. There is a lack of data regarding outcomes after HTx in patients with ASD.Methods:The NIS was queried from 2011-2019 for relevant ICD-9 and ICD-10 codes to identify patients with and without ASD who underwent HTx. Baseline characteristics and in-hospital outcomes between patients were compared. Binary logistic regression was used to adjust outcomes for significantly different baseline characteristics (p
Risultati per: Atlante della salute mentale 2011
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Abstract 16693: Trends in the Use of Oral Anticoagulation for Nonvalvular Atrial Fibrillation Vary by Specialty: Real World Results From a Large Integrated Health Care System 2011-2022
Circulation, Volume 148, Issue Suppl_1, Page A16693-A16693, November 6, 2023. Introduction:Direct Oral anticoagulants (DOACs) have demonstrated superiority or non inferiority to vitamin K antagonists (VKAs) for stroke/embolic prevention in patients with nonvalvular atrial fibrillation (NVAF). However, clinical inertia may delay widespread adoption of newer therapies in medicine.Hypothesis:We evaluated whether uptake of DOACs into clinical medicine varied by physician specialty.Methods:We performed a retrospective review of patients with NVAF within the Geisinger Health System from 2011-2022. Longitudinal yearly trends for new/initial prescriptions (Rx) of DOAC vs VKA by cardiology or primary care (PCP) specialtiesResults:We identified patients with NVAF initiated on an oral anticoagulant from the years 2011 through 2023. Figures 1 and 2 demonstrate a statistically significant linear yearly increase in new Rx for DOACs for both cardiology and PCP specialties.By 2022, DOACs currently account for 96% of all new oral anticoagulant Rx by cardiologists and 90% of Rx by PCP. New Rx for DOAC by PCP lagged cardiology at all time points. Cardiology initial Rx >50% DOAC by 2015 while PCP did not achieve this mark until 2018.Conclusions:In this real-world setting, we observed a significant increase in DOAC use as the initial prescription for patients with NVAF by both cardiology and primary care specialties.Significant difference in the adoption of DOAC was noted between cardiology and primary care specialties.Primary care use of DOAC as first Rx for NVAF increased over time but lagged cardiology by 2-3 years.
Abstract 18362: Endovascular versus Surgical Revascularization for Chronic Limb Threatening Ischemia: A Comparison of Re-Admission Rates From NSQIP Database (2011-2021)
Circulation, Volume 148, Issue Suppl_1, Page A18362-A18362, November 6, 2023. Background:Data regarding relative readmission rates following endovascular and surgical revascularization for chronic limb threatening ischemia (CLTI) are conflicting. Understanding comparative readmission rates may inform selection of the most appropriate revascularization modality for these patients.Research Question:What are the differences in 30-day readmission rates between endovascular and surgical interventions for CLTI?Methods:The 2012 to 2021 American College of Surgeons National Surgical Quality Improvement Program’s (NSQIP) Targeted Vascular Module was used to identify patients discharged alive after surgical or endovascular revascularization for CLTI. The primary outcome was 30-day readmission following the index procedure; secondary outcomes included survival, major re-intervention of the treated arterial segment, amputation, untreated loss of patency of bypass graft, bleeding requiring transfusion or re-intervention, major adverse cardiovascular events (MACE) and major adverse limb events (MALE). Revascularization modality was related to 30-day readmission using multivariable logistic regression.Results:We identified 30,390 patients (mean age 69±11.5 years, male 62.8%, mean BMI 26.9±8.1 kg/m2, 61% Caucasian, 20.2% Black). When compared with endovascular therapy, surgical bypass was associated with higher 30-day readmission (13.3% vs. 8.6%, p =
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Regulatory Review Duration and Differences in Submission Times of Drugs in the United States and Europe, 2011 to 2020
Annals of Internal Medicine, Volume 176, Issue 10, Page 1413-1418, October 2023.
Regulatory Review Duration and Differences in Submission Times of Drugs in the United States and Europe, 2011 to 2020
Annals of Internal Medicine, Volume 176, Issue 10, Page 1413-1418, October 2023.