This randomized trial assesses the effect of ponatinib vs imatinib combined with low-intensity chemotherapy on disease remission in adults with newly diagnosed Philadelphia chromosome–positive acute lymphoblastic leukemia (ALL).
Risultati per: Terapia antibiotica: breve durata vs. lunga durata
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Oral Minoxidil vs Topical Minoxidil for Male Androgenetic Alopecia
This randomized clinical trial compares the efficacy, safety, and tolerability of daily oral minoxidil, 5 mg, with twice-daily topical minoxidil, 5%, for 24 weeks in the treatment of male androgenetic alopecia.
SGLT2i vs Sulfonylureas for Gout Prevention Among Patients With Type 2 Diabetes Receiving Metformin
This cohort study uses target trial emulation to evaluate risk of incident gout and rate of recurrent gout flares in patients with type 2 diabetes initiating sodium-glucose cotransporter-2 inhibitors (SGLT2i) vs sulfonylureas.
Gefitinib vs Gefitinib Plus Pemetrexed and Carboplatin Chemotherapy in Lung Cancer
This randomized clinical trial examines whether adding chemotherapy with pemetrexed and carboplatin to gefitinib improves survival among patients with epidermal growth factor receptor (EGFR)–variant non–small cell lung cancer.
Aspirin vs Placebo as Adjuvant Therapy for Breast Cancer
This study examines the potential benefits of aspirin as adjuvant therapy for survivors of early breast cancer.
Cefepime vs. Piperacillin-Tazobactam for Sepsis: The Debate Continues
A retrospective study suggests that PTZ for initial empirical management of undifferentiated sepsis is associated with higher mortality.
Local vs. General Anesthesia for Elective Endovascular AAA Repair
In older patients with asymptomatic abdominal aortic aneurysms, outcomes were slightly better with local anesthesia.
New use of thiazide diuretics vs. nonthiazide antihypertensive drugs was linked to hyponatremia over 2 y
Annals of Internal Medicine, Ahead of Print.
New use of thiazide diuretics vs. nonthiazide antihypertensive drugs was linked to hyponatremia over 2 y
Annals of Internal Medicine, Ahead of Print.