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Abstract TP99: Non-invasive Aortic Pulse Wave Velocity Is Related To Gold Standard Carotid-femoral Pulse Wave Velocity: Implications For Monitoring Large Artery Stiffness In The Clinic

Stroke

Stroke, Volume 54, Issue Suppl_1, Page ATP99-ATP99, February 1, 2023. Introduction:Aortic stiffness is an independent predictor of fatal stroke in both hypertensive populations and healthy subjects, but traditional monitoring methods have had difficulty being incorporated into routine practice. The gold standard, carotid-femoral pulse wave velocity (cfPWV), poses methodological challenges as this method bypasses the most distensible vessel, the proximal aorta. We propose a new method, aortic arch pulse wave velocity (aaPWV) assessed via ultrasound, which encompasses the proximal aorta and can be performed during standard cardiac echocardiography. We sought to determine if the two methods were related.Methods:We recruited 44 healthy volunteers (38.1y [SEM: 2.39], range 20-62y, 80% female) for this study. Both aaPWV and cfPWV were measured by the wave-foot method using a commercial Logic S8 Ultrasound system (GE Healthcare) with synchronous electrocardiogram. cfPWV was calculated by determining the time delay between the two vessels and dividing by the measured distance between the two sites. aaPWV was calculated by determining the time delay between onset of aortic ejection from the apical 5-chamber view and the arrival of the pulse wave at the start of descending aorta in the suprasternal view. Distance for aaPWV was estimated using regression equation from the literature.Results:Paired t-tests revealed cfPWV was significantly greater than aaPWV (5.98 ± 0.17m/s vs. 4.7 ± 0.29m/s; P

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Febbraio 2023

Heart Disease and Stroke Statistics—2023 Update: A Report From the American Heart Association

Circulation

Circulation, Ahead of Print. BACKGROUND:The American Heart Association, in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, diet, and weight) and health factors (cholesterol, blood pressure, and glucose control) that contribute to cardiovascular health. The Statistical Update presents the latest data on a range of major clinical heart and circulatory disease conditions (including stroke, congenital heart disease, rhythm disorders, subclinical atherosclerosis, coronary heart disease, heart failure, valvular disease, venous disease, and peripheral artery disease) and the associated outcomes (including quality of care, procedures, and economic costs).METHODS:The American Heart Association, through its Epidemiology and Prevention Statistics Committee, continuously monitors and evaluates sources of data on heart disease and stroke in the United States to provide the most current information available in the annual Statistical Update with review of published literature through the year before writing. The 2023 Statistical Update is the product of a full year’s worth of effort in 2022 by dedicated volunteer clinicians and scientists, committed government professionals, and American Heart Association staff members. The American Heart Association strives to further understand and help heal health problems inflicted by structural racism, a public health crisis that can significantly damage physical and mental health and perpetuate disparities in access to health care, education, income, housing, and several other factors vital to healthy lives. This year’s edition includes additional COVID-19 (coronavirus disease 2019) publications, as well as data on the monitoring and benefits of cardiovascular health in the population, with an enhanced focus on health equity across several key domains.RESULTS:Each of the chapters in the Statistical Update focuses on a different topic related to heart disease and stroke statistics.CONCLUSIONS:The Statistical Update represents a critical resource for the lay public, policymakers, media professionals, clinicians, health care administrators, researchers, health advocates, and others seeking the best available data on these factors and conditions.

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Gennaio 2023
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