Risultati per: Farmaci per la disfunzione erettile collegati a un ridotto rischio di malattia di Alzheimer

Medicina di famiglia a rischio per carenze di nuove leve e pensionamenti anticipati, Silvestro Scotti: «Subito l’Atto d’indirizzo per il rinnovo dell’ACN 2019-2021»

Medicina di famiglia a rischio per carenze di nuove leve e pensionamenti anticipati, Silvestro Scotti: «Subito l’Atto d’indirizzo per il rinnovo dell’ACN 2019-2021»

Medicina di famiglia a rischio per carenze di nuove leve e pensionamenti anticipati, Silvestro Scotti: «Subito l’Atto d’indirizzo per il rinnovo dell’ACN 2019-2021»

Burocrazia, pochi fondi, misure complicate per la privacy e mancato adeguamento alle nuove regole Ue sulle sperimentazioni cliniche

Stroke, Ahead of Print. BACKGROUND:Species-specific differences in astrocytes and their Alzheimer disease-associated pathology may influence cellular responses to other insults. Herein, human glial chimeric mice were generated to evaluate how Alzheimer disease predisposing genetic background in human astrocytes contributes to behavioral outcome and brain pathology after cortical photothrombotic ischemia.METHODS:Neonatal (P0) immunodeficient mice of both sexes were transplanted with induced pluripotent stem cell–derived astrocyte progenitors from Alzheimer disease patients carryingPSEN1exon 9 deletion (PSEN1ΔE9), with isogenic controls, with cells from a healthy donor, or with mouse astrocytes or vehicle. After 14 months, a photothrombotic lesion was produced with Rose Bengal in the motor cortex. Behavior was assessed before ischemia and 1 and 4 weeks after the induction of stroke, followed by tissue perfusion for histology.RESULTS:Open field, cylinder, and grid-walking tests showed a persistent locomotor and sensorimotor impairment after ischemia and female mice had larger infarct sizes; yet, these were not affected by astrocytes withPSEN1ΔE9 background. Staining for human nuclear antigen confirmed that human cells successfully engrafted throughout the mouse brain. However, only a small number of human cells were positive for astrocytic marker GFAP (glial fibrillary acidic protein), mostly located in the corpus callosum and retaining complex human-specific morphology with longer processes compared with host counterparts. While host astrocytes formed the glial scar, human astrocytes were scattered in small numbers close to the lesion boundary. Aβ (beta-amyloid) deposits were not present inPSEN1ΔE9 astrocyte-transplanted mice.CONCLUSIONS:Transplanted human cells survived and distributed widely in the host brain but had no impact on severity of ischemic damage after cortical photothrombosis in chimeric mice. Only a small number of transplanted human astrocytes acquired GFAP-positive glial phenotype or migrated toward the ischemic lesion forming glial scar.PSEN1ΔE9 astrocytes did not impair behavioral recovery after experimental stroke.

Al via le somministrazioni del vaccino bivalente su Omicron 1. Ma a fine mese potrebbe arrivare quello aggiornato sulla sottovariante Omicron 5

Finanziato con 23 milioni dalla Commissione europea, il progetto ha l’obiettivo di sviluppare un ecosistema di ricerca e innovazione che faciliti lo sviluppo rapido ed economicamente vantaggioso di farmaci attraverso il drug repurposing. L’Italia è in prima fila con 4 organizzazioni

This JAMA Internal Medicine Patient Page describes use of aducanumab for treatment of Alzheimer disease, including potential benefits, harms, and concerns about use.

Le aziende disinvestono perchè queste terapie non sono sostenibili. L’ultimo caso riguarda Strimvelis, per la cura della rara immunodeficienza Ada-Scid. L’appello di Fondazione Telethon per scongiurare il ritiro dal mercato può costituire un precedente per superare le sfide del mercato