Risultati per: L’inibizione di un enzima uccide selettivamente le cellule di melanoma

In Reply We appreciate the tremendous enthusiasm with which Drs He and Huang read our article highlighting the weak association between proxies for UV radiation exposure and melanoma incidence across US counties. Although this revelation may be surprising to some readers and could shatter long-standing perceptions for others, it is not a new finding. The meta-analytic relative risk for the strongest UV-related risk factor—sunburn history—is only 2.0. This relatively weak association is not recognized by the wider public because sun exposure and its association with melanoma are too often (and inappropriately) compared with smoking and lung cancer (relative risk, 10.0-20.0). Although UV radiation exposure may be a modifiable risk factor for melanoma, it is certainly not formidable.

This JAMA Patient Page describes melanoma, its risk factors, diagnosis, treatment, and prognosis.

Lo studio dei ricercatori dell’Ifom di Milano e del Cnr-Igm di Pavia, appena pubblicato su Nature Cell Biology, dimostra che il coronavirus viola i sistemi delle cellule, ne danneggia il Dna e impedisce di ripararlo

Lo studio dei ricercatori dell’Ifom di Milano e del Cnr-Igm di Pavia, appena pubblicato su Nature Cell Biology, dimostra che il coronavirus viola i sistemi delle cellule, ne danneggia il Dna e impedisce di ripararlo

New England Journal of Medicine, Volume 388, Issue 9, Page 859-860, March 2023.

New England Journal of Medicine, Volume 388, Issue 9, Page 813-823, March 2023.

Inaugurato nei giorni dei primi lockdown (marzo 2020) poco fuori Amsterdam, ecco come vengono prodotti gli anti tumorali biologici nel grande stabilimento costato 135 milioni di euro

Tecniche imaging per un nuovo metodo identificazione neoplasia

This cohort study examines the association between tumor-infiltrating lymphocyte classification and disease progression among patients with metastatic primary cutaneous melanoma receiving checkpoint inhibitor therapy.

This randomized clinical trial examines quality of life in patients with resected melanoma at high risk for relapse who were treated with adjuvant pembrolizumab vs standard of care with either ipilimumab or high-dose interferon α 2b.

Terapie personalizzate, più efficaci in base al tipo di malattia

Objective
Although black patients are more likely to have advanced melanomas at diagnosis, with a 5-year survival rate among black patients of 70% compared with 92% for white patients, black people are generally not the focus of melanoma public health campaigns. We sought to explore awareness and perspectives of melanoma among black people to inform the development of relevant and valued public health messages to promote early detection of melanoma.

Design
Inductive thematic analysis of in-depth semistructured interviews.

Setting
Interviews were conducted with participants via video software or telephone in the USA.

Participants
Participants were adults from the USA who self-identified as African American or black. Recruitment flyers were posted around the San Francisco Bay Area and shared on our team Facebook page, with further participants identified through snowball sampling.

Results
We interviewed 26 participants from 10 different states. Overall, 12 were men and 14 were women, with a mean age of 43 years (range 18–85). We identified five key themes regarding melanoma awareness in black people: (1) lack of understanding of term ‘melanoma’ and features of skin cancer; (2) do not feel at risk of melanoma skin cancer; (3) surprise that melanoma can occur on palms, soles and nails; (4) skin cancer awareness messages do not apply to or include black people; and (5) Importance of relationship with healthcare and habits of utilisation.

Conclusions
Analysis of these in-depth semistructured interviews illuminate the pressing need for health information on melanoma designed specifically for black people. We highlight two key points for focused public health messaging: (1) melanoma skin cancer does occur in black people and (2) high-risk sites for melanoma in black people include the palms, soles and nail beds. Therefore, public health messages for black people and their healthcare providers may involve productively checking these body surface areas.

Confindustria dispositivi medici, a rischio lavoro e salute

È LAP1 e aumento dei livelli è collegato a prognosi sfavorevole

In Reply We read with interest the Letter to the Editor written by Pham and Dalle in response to our prospective, multicenter randomized clinical trial that evaluated the hypothesis that reflectance confocal microscopy (RCM) reduces unnecessary lesion excision in equivocal lesions for the diagnosis of melanoma. We thank the editor for the opportunity to further clarify the inclusion criteria of our study.