CREEPING FAT-DERIVED FREE FATTY ACIDS INDUCE HYPERPLASIA OF INTESTINAL MUSCULARIS PROPRIA MUSCLE CELLS – A NOVEL LINK BETWEEN FAT AND INTESTINAL STRICTURE FORMATION IN CROHN’S DISEASE

In Crohn’s disease (CD) wrapping of mesenteric fat around the bowel wall, so called ‘creeping fat’, is highly associated with strictures. The strongest contributor to luminal narrowing in strictures is a thickening of the human intestinal muscularis propria (MP). We hence investigated creeping fat derived factors and their effect on mechanisms of human intestinal MP smooth muscle cell (HIMC) hyperplasia.

Read More
Novembre 2024