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This systematic review and bayesian meta-analysis investigated whether administration of β-lactam antibiotics by prolonged infusion reduces 90-day mortality compared with intermittent infusion in adult patients with sepsis or septic shock.
This clinical trial compares the efficacy of continuous vs intermittent infusion of a β-lactam antibiotic (piperacillin-tazobactam or meropenem) in decreasing all-cause mortality at 90 days in critically ill patients with sepsis.
The Surviving Sepsis Campaign guidelines recommend that adults with sepsis or septic shock should receive prolonged infusion of β-lactams (after an initial bolus) vs conventional intermittent infusion. However, this is only a weak recommendation based on moderate quality of evidence. In this issue of JAMA, 2 major new contributions strengthen the evidence for this recommendation.
Tecnologia dell’Università Carlo Bo esplora uso di globuli rossi
This multicenter, cluster-randomized, noninferiority trial investigates the effectiveness of povidone iodine vs chlorhexidine gluconate in alcohol as preoperative skin antisepsis in preventing surgical site infections in adults undergoing abdominal or cardiac surgery.
This retrospective study showed lower incidence for several adverse outcomes with tirzepatide, with some caveats.
Annals of Internal Medicine, Ahead of Print.
Annals of Internal Medicine, Ahead of Print.
Annals of Internal Medicine, Ahead of Print.
Annals of Internal Medicine, Ahead of Print.
Annals of Internal Medicine, Ahead of Print.
Annals of Internal Medicine, Ahead of Print.
This randomized clinical trial examines the relative effectiveness of electronic cigarettes in smoking cessation.
Vaccines have proven to be the single most effective weapon in the global fight against COVID-19, substantially reducing COVID-19–related illness, hospitalization, and death. As antigenically distinct strains of SARS-CoV-2 emerge seasonally and geographically, it is critical to evaluate the importance of regular boosting and updating vaccines to match dominant circulating variants.
This study assesses the accuracy of fluorine-18 prostate-specific membrane antigen–1007 positron emission tomography (PET)/computed tomography (CT) compared to multiparametric magnetic resonance imaging (MRI) in locoregional staging of prostate cancer.
Studio identifica i pazienti a rischio di chirurgia inefficace
