Risultati per: Terapia antibiotica: breve durata vs. lunga durata

This Viewpoint discusses possible outcomes of predictive analytic tool use in charity care determinations: hospital revenue and patient debt.

To the Editor A recent study reported on the absence of a statistically significant benefit of aspirin at 300 mg/d for recurrence and survival in patients with breast cancer. In accordance with these findings, the authors advised against the routine use of aspirin as an adjunct treatment in breast cancer.

In Reply Alliance A011502, a randomized trial of aspirin 300 mg daily compared with placebo among 3020 survivors of high-risk nonmetastatic breast cancer, was terminated early due to lack of benefit from aspirin. Dr Thorat and colleagues note that for some cancers (eg, colorectal cancer) and different settings (eg, primary prevention), the time course of benefit can differ. However, in the adjuvant setting, it would still be most appropriate to use the standard stopping rules applied to adjuvant treatments such as hormonal therapy for hormone receptor–positive cancers, which, as Thorat and colleagues point out, can have a more indolent course with late recurrences. In our trial, the futility bound was crossed with a numerically worse hazard ratio for invasive disease–free survival (hazard ratio, 1.27; 95% CI, 0.99-1.63; P = .06), making it unlikely that a benefit would have been observed with further follow-up.

Endocrinologi, troppi timori, non si spiegano bene i vantaggi

This randomized clinical trial compares the effect of continued use of renin-angiotensin system inhibitors (RASIs) vs discontinued use of RASIs before major noncardiac surgery on postoperative complications.

In aumento, un terzo dei pazienti riceve diagnosi dopo 5 anni

In aumento, un terzo dei pazienti riceve diagnosi dopo 5 anni

Colpiti in 500mila, il farmaco è per forme moderate e severe

Colpiti in 500mila, il farmaco è per forme moderate e severe

Nella forma metastatica ormonosensibile

Ha effetti positivi sui grassi e gli zuccheri nel sangue

This population-based cohort study uses health care utilization data for pregnant individuals with opioid use disorder to compare neonatal and maternal outcomes following prenatal exposure to buprenorphine combined with naloxone vs buprenorphine alone.

Sindrome di Leigh,progetto vincitore bando Multi-round Telethon

Per l’amaurosi congenita di Leber risultati duraturi e notevoli

Ok da Aifa, riduce i sintomi intestinali senza l’uso di steroidi