Risultati per: Terapia antibiotica: breve durata vs. lunga durata

Annals of Internal Medicine, Ahead of Print.

Annals of Internal Medicine, Ahead of Print.

Annals of Internal Medicine, Ahead of Print.

This noninferiority randomized clinical trial investigates whether tenecteplase is noninferior to alteplase for the treatment of Chinese patients with acute ischemic stroke eligible for intravenous thrombolysis within 4.5 hours after symptom onset.

This multicenter retrospective cohort study examines the comparative effectiveness of lactated Ringer solution vs normal saline for fluid resuscitation in inpatients with sickle cell disease and vaso-occlusive episodes.

This randomized clinical trial examines whether stereotactic body radiotherapy improves local control compared with hypofractionated conventional radiotherapy.

This randomized clinical trial compares the effect of transperineal vs transrectal prostate biopsy on infection rates after biopsy.

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In a randomized trial, procedure-related infection was less common with the transperineal approach.

To the Editor A recent study provided a robust analysis of the association between the reduction in stage III to IV cancer diagnoses and overall survival gains in historical cancer screening trials, and the accompanying Editorial added an important epidemiological perspective. However, the relationship between cancer stage at diagnosis and survival is not static. Data from the studies examined, many of which were initiated 30 to 40 years ago, are of questionable relevance in the modern era.

To the Editor A recent study offered valuable insights into the management and prognosis of advanced cancer. Nevertheless, we have several concerns about this article.

In Reply Our study compared the end points of cancer-specific mortality and late-stage cancer in randomized clinical trials of cancer screening. Drs Kim and Gibbs write that the relationship between these could be affected by changes in cancer staging and treatment. We agree that this is true not only for our comparison of end points, but for cancer screening in general. For example, a screening test that is effective at reducing cancer mortality could become ineffective if new treatments decrease differences in survival between stages. For the cancer types in our study, Surveillance, Epidemiology, and End Results data generally show survival improvements over time across all stages.

This randomized clinical trial assesses the effect of pulmonary vein isolation vs a sham procedure on atrial fibrillation burden at 6 months in patients with symptomatic paroxysmal or persistent atrial fibrillation.

This randomized, multisite, comparative effectiveness trial investigates whether early palliative care delivered via video or in-person visits demonstrated equivalent effects on quality of life for patients with advanced non–small cell lung cancer and their caregivers.