Risultati per: Papilloma virus

Studio Usa, supporto di ossigeno e ricovero in terapia intensiva

Ecdc:’Si valuti invito a non volare’. Oms, Kraken non è più grave

New England Journal of Medicine, Volume 387, Issue 25, December 2022.

Objectives
Respiratory syncytial virus (RSV) is one of the most important causes of lower respiratory tract illnesses. In this study, we examined the number and severity of RSV infections among adult patients. The underlying diseases and background information of patients with RSV were examined and compared with the patients with influenza.

Design
Retrospective cohort study.

Setting
Patients receiving tertiary care services in Kuopio University Hospital (KUH) district in Eastern Finland.

Participants
725 patients (152 with RSV infection and 573 with influenza) treated in KUH between November 2017 and May 2018.

Primary and secondary outcome measures
Hospitalisation and mortality.

Results
Compared with influenza, RSV caused a more serious disease in terms of hospitalisation (84.2% vs 66.0%, p

New England Journal of Medicine, Ahead of Print.

La conferma da studio GB ma basta lavare mani e prodotti freschi

Con arrivo dei mesi più freddi. BQ1.1sta rimpiazzando BA5

Objectives
To support the Zika virus (ZIKV) Individual Participant Data (IPD) Consortium’s efforts to harmonise and analyse IPD from ZIKV-related prospective cohort studies and surveillance-based studies of pregnant women and their infants and children; we developed and disseminated a metadata survey among ZIKV-IPD Meta-Analysis (MA) study participants to identify and provide a comprehensive overview of study-level heterogeneity in exposure, outcome and covariate ascertainment and definitions.

Setting
Cohort and surveillance studies that measured ZIKV infection during pregnancy or at birth and measured fetal, infant, or child outcomes were identified through a systematic search and consultations with ZIKV researchers and Ministries of Health from 20 countries or territories.

Participants
Fifty-four cohort or active surveillance studies shared deidentified data for the IPD-MA and completed the metadata survey, representing 33 061 women (11 020 with ZIKV) and 18 281 children.

Primary and secondary outcome measures
Study-level heterogeneity in exposure, outcome and covariate ascertainment and definitions.

Results
Median study sample size was 268 (IQR=100, 698). Inclusion criteria, follow-up procedures and exposure and outcome ascertainment were highly heterogenous, differing meaningfully across regions and multisite studies. Enrolment duration and follow-up for children after birth varied before and after the declaration of the Public Health Emergency of International Concern (PHEIC) and according to the type of funding received.

Conclusion
This work highlights the logistic and statistical challenges that must be addressed to account for the multiple sources of within-study and between-study heterogeneity when conducting IPD-MAs of data collected in the research response to emergent pathogens like ZIKV.

Lanciata da Sanofi con pediatri, neonatologi,esperti prevenzione

This study uses electronic medical record data to describe monkeypox infections after a single dose of Modified Vaccinia Ankara-Bavarian Nordic vaccine, a live, nonreplicating vaccine indicated for prevention of smallpox and monkeypox infection in adults.

Mille infettivologi al XXI congresso Simit a Roma

New England Journal of Medicine, Ahead of Print.

Annals of Internal Medicine, Volume 175, Issue 12, Page 1639-1647, December 2022.

Annals of Internal Medicine, Ahead of Print.

Mohraz M, Salehi M, Tabarsi P, et al. Safety and immunogenicity of an inactivated virus particle vaccine for SARS-CoV-2, BIV1-CovIran: findings from double-blind, randomised, placebo-controlled, phase I and II clinical trials among healthy adults. BMJ Open 2022;12:e056872. doi: 10.1136/bmjopen-2021-056872 In the corrected version of the article, the competing interest statements for authors Hamed Hosseini, Minoo Mohraz, and Payam Tabaris have been changed. The original article indicated they had no competing interests. It now states the following: HH: as manager of the Clinical Trial Center (CTC), an academic CRO affiliated with Tehran University of Medical Sciences, Tehran, Iran, I was responsible for the conduct and monitoring of clinical trials. I was a non-voting member of the Data Safety Monitoring Board, as mandated by the national regulatory authority. MM: a research contract between Shifapharmed (sponsor) and Iranian Research Centre for HIV/AIDS (IRCHA) for supervising all clinical trial activities of phases one…

Genital herpes simplex virus (HSV) infections are among the most common sexually transmitted infections encountered by humans and, in 2018, were estimated to occur in approximately 27% of US adults. There is no cure for HSV infection; consequently, infection can be transmitted from individual to individual, most often because of asymptomatic viral shedding. Thus, the reservoir of individuals infected with HSV continues to increase.