Risultati per: Trattamento del cancro del colon retto metastatico

L’International Agency for Research on Cancer (Iarc), l’agenzia dell’Oms specializzata nella ricerca sul cancro, potrebbe presto classificare il dolcificante aspartame come “possibile cancerogeno per l’uomo”. È quanto anticipa la Reuters sul proprio sito citando fonti anonime

Oncologi, ‘trasmissione per via sessuale. La vaccinazione è importante’

Introduction
Within the last two decades, major advances have been made in the surgical approach for patients with colorectal cancer. However, to this day we face considerable challenges in reducing surgery-related complications and improving long-term oncological outcomes. Unprecedented response rates have been achieved in studies investigating immunotherapy in patients with mismatch repair deficient (dMMR) colorectal cancer. This has raised the question of whether neoadjuvant immunotherapy may change the standard of care for localised dMMR colon cancer and pave the way for organ-sparing treatment.

Methods and analysis
This is an investigator-initiated, multicentre, prospective, single-arm, phase II study in patients with stage I–III dMMR colon cancer scheduled for intended curative surgery. Eighty-five patients will be treated with one dose of pembrolizumab (4 mg/kg) and within 5 weeks will undergo a re-evaluation with an endoscopy and a CT scan—to assess tumour response—before standard resection of the tumour. The primary endpoint is the number of patients with pathological complete response, and secondary endpoints include safety (number and severity of adverse events) and postoperative surgical complications. In addition, we aspire to identify predictive biomarkers that can point out patients that achieve pathological complete response.

Ethics and dissemination
The Regional Committee for Health Research and Ethics and the Danish Medicines Agency have approved this study. The study will be performed according to the Helsinki II declaration. Written informed consent will be obtained from all participants. The results of the study will be submitted to peer-reviewed journals for publication and presented at international congresses.

Trial registration number
NCT05662527.

Contrasto a tabagismo fondamentale contro il tumore al polmone

Grazie anche all’immunoncologia. La Campagna ‘Lo so anch’io’ per conoscerla

Grazie a immunoncologia.Campagna ‘Lo so anch’io ‘ per conoscerla