Risultati per: È confermato il legame tra la malattia di Alzheimer e microbiota intestinale

Esperta,’spesso asintomatica. Prevenzione con test sangue-urine’. Il 14 marzo la Giornata mondiale

Solo l’1% delle ricerche sono dedicate a condizioni specifiche di genere. Intervista alla neuroscienziata Antonella Santuccione Chadha: «Donne enorme bacino di pazienti sottodiagnosticato»

These treatments are recommended “conditionally” for certain groups of patients with Clostridioides difficile colitis.

Selumetinib riduce i neurofibromi legati alla neurofibromatosi

New England Journal of Medicine, Volume 390, Issue 10, March 2024.

Rapporto Censis, poco più del 60% crede che il cancro si possa prevenire

Poco più del 60% crede che il cancro si possa prevenire

Messaggio del presidente della Repubblica nella Giornata Mondiale delle Malattie Rare

E’ associata alla mutazione genetica

New England Journal of Medicine, Volume 390, Issue 9, Page 866-867, February 2024.

A commercially available blood test that measures levels of a tau protein known as phosphorylated tau 217, or p-tau217, was able to identify people whose brains showed signs of Alzheimer disease pathology, according to data from an observational study. The research involved about 800 participants with and without cognitive impairment.

Objective
Early disease prediction is challenging in acute pancreatitis (AP). Here, we prospectively investigate whether the microbiome predicts severity of AP (Pancreatitis—Microbiome As Predictor of Severity; P-MAPS) early at hospital admission.

Design
Buccal and rectal microbial swabs were collected from 424 patients with AP within 72 hours of hospital admission in 15 European centres. All samples were sequenced by full-length 16S rRNA and metagenomic sequencing using Oxford Nanopore Technologies. Primary endpoint was the association of the orointestinal microbiome with the revised Atlanta classification (RAC). Secondary endpoints were mortality, length of hospital stay and severity (organ failure >48 hours and/or occurrence of pancreatic collections requiring intervention) as post hoc analysis. Multivariate analysis was conducted from normalised microbial and corresponding clinical data to build classifiers for predicting severity. For functional profiling, gene set enrichment analysis (GSEA) was performed and normalised enrichment scores calculated.

Results
After data processing, 411 buccal and 391 rectal samples were analysed. The intestinal microbiome significantly differed for the RAC (Bray-Curtis, p value=0.009), mortality (Bray-Curtis, p value 0.006), length of hospital stay (Bray-Curtis, p=0.009) and severity (Bray-Curtis, p value=0.008). A classifier for severity with 16 different species and systemic inflammatory response syndrome achieved an area under the receiving operating characteristic (AUROC) of 85%, a positive predictive value of 67% and a negative predictive value of 94% outperforming established severity scores. GSEA revealed functional pathway units suggesting elevated short-chain fatty acid (SCFA) production in severe AP.

Conclusions
The orointestinal microbiome predicts clinical hallmark features of AP, and SCFAs may be used for future diagnostic and therapeutic concepts.

Trial registration number
NCT04777812.

New England Journal of Medicine, Volume 390, Issue 8, Page 761-763, February 2024.