Background
Intention-to-treat analyses of the Omega-3 to Reduce the Incidence of Prematurity (ORIP) trial found that omega-3 (n-3) fatty acid supplementation reduces the risk of prematurity in the subgroup of women with a singleton pregnancy and low n-3 status early in pregnancy, but not overall. However, results may have been influenced by less-than-optimal compliance.
Objectives
To identify predictors of compliance with n-3 supplementation and determine treatment effects among compliers.
Design
Exploratory analyses of a multicentre-blinded randomised trial.
Setting
6 tertiary care centres in Australia.
Participants
5328 singleton pregnancies.
Interventions
Daily capsules containing 900 mg n-3 long-chain polyunsaturated fatty acids or vegetable oil, consumed from before 20 weeks gestation until 34 weeks gestation.
Outcome measures
Early preterm (