Risultati per: Helicobacter Pylori: algoritmo terapeutico di eradicazione

The current European guidelines (Maastricht VI/Florence consensus report) on the management of Helicobacter pylori infection1 recommend population-based H. pylori screening programmes for asymptomatic individuals in the general population to eradicate the microorganism for gastric cancer prevention. However, this is expected to result in a considerable increase in antibiotic use2 as half of the global population are estimated to be infected.3 Therefore, the guidelines suggest that caution is required in choosing the appropriate antibiotics to minimise antimicrobial resistance.1 The importance of gut resistome induction following H. pylori eradication therapies has been debated for years, and the available information is controversial; the general thought is that normal gut microbiota is restored 3–6 months after antibiotic treatment.4 Therefore, we conducted a randomised controlled clinical trial as part of the GISTAR study5 in Latvia by evaluating alterations in gut microbiota before…

We read with great interest the recent publication by Rugge et al,1 in which the authors conducted a cohort study to evaluate the association between autoimmune gastritis (AIG) and gastric cancer (GC). No excess risk of gastric or other malignancies was observed over a cumulative follow-up time of 10 541 person-years, except for (marginally significant) thyroid cancer (standardised incidence ratio=3.09; 95 % CI 1.001 to 7.20). They concluded that, compared with the general population, corpus-restricted inflammation/atrophy observed in patients with AIG do not increase the risk of GC. The excess GC risk reported in patients with AIG may be influenced by unrecognised previous/current Helicobacter pylori comorbidity. We previously reported 76 GC cases, positive for the antiparietal cell antibody (APCA) test; among them, 8 cases developed cancer in pure AIG stomachs without an apparent history of H. pylori infection.2 Nevertheless, in regions such as Japan, where the…