Introduction
Familial hypercholesterolaemia (FH) is a frequent (1:300) autosomal dominantly inherited condition which causes premature (women
Risultati per: Screening per i disturbi lipidici nei bambini e negli adolescenti
Questo è quello che abbiamo trovato per te
Lung CAncer SCreening in French women using low-dose CT and Artificial intelligence for DEtection: the CASCADE study protocol
Introduction
Lung cancer screening (LCS) using low-dose CT has been demonstrated to reduce lung cancer-related mortality in large randomised controlled trials. Moving from trials to practice requires answering practical questions about the level of expertise of CT readers, the need for double reading as in trials and the potential role of artificial intelligence (AI). In addition, most LCS studies have predominantly included male participants with women being under-represented, even though the benefit of screening is greater for them. Thus, this study aims to compare the performance of a single CT reading by general radiologists trained in LCS using AI as a second reader to that of a double reading by expert thoracic radiologists, in a campaign for low-dose CT screening in high-risk women.
Methods and analysis
This observational cohort study will recruit 2400 asymptomatic women aged between 50 and 74 years, current or former smokers with at least a 20 pack-year smoking history, in 4 different French district areas. Assistance with smoking cessation will be offered to current smokers. An initial low-dose CT scan will be performed, with subsequent follow-ups at 1 year and 2 years. The primary objective is to compare CT scan readings by a single LCS-trained, AI-assisted radiologist to that of an expert double reading. The secondary objectives are: to evaluate the performance of AI as a stand-alone reader; the adherence to screening of female participants; the influence on smoking cessation; the psychological consequences of screening; the detection of chronic obstructive pulmonary disease (COPD), coronary artery disease and osteoporosis on low-dose CT scans and the costs incurred by screening.
Ethics and dissemination
Ethics approval was obtained from the Comité de Protection des Personnes Sud-Est 1 (ethics approval number: 2021-A02265-36 with an amendment on 15 July 2022). Trial results will be disseminated at conferences, through relevant patient groups and published in peer-reviewed journals.
Trial registration number
NCT05195385.
Assistenza psicologica a bambini e adolescenti con diabete
Scienza spiegata ai bambini, arriva progetto MyEdu-Humanitas
Corso multimediale rivolto alle scuole,primi episodi sui vaccini
Scienza spiegata ai bambini,arriva progetto MyEdu-Humanitas
Corso multimediale rivolto alle scuole,primi episodi sui vaccini
Undiagnosed inflammatory bowel disease among individuals undergoing colorectal cancer screening: a nationwide Danish cohort study 2014-2018
Chiu et al recently investigated the long-term effectiveness of national faecal immunochemical test (FIT) screening for colorectal cancer (CRC).1 They demonstrated reduced risk of advanced-stage CRC and its mortality with larger reductions in distal CRC as compared with proximal CRC. An additional outcome of the CRC screening programme may be early detection of other diseases, such as inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD). The prevalence of IBD is up to 1% in westernised countries.2 3 However, symptoms of IBD vary and may increase time to diagnosis.4 Correct and early diagnosis is important to improve treatment outcomes and patients’ quality of life.5 Although early markers of IBD, such as antimicrobial antibodies and serum proteins, are emerging,6 7 colonoscopy still remains one of the only methods to detect early IBD. Since…
Prostate Cancer Screening with PSA and MRI Followed by Targeted Biopsy Only
New England Journal of Medicine, Volume 387, Issue 23, Page 2126-2137, December 2022.
In older men, an invitation for comprehensive CV screening did not reduce death at 5.6 y
Annals of Internal Medicine, Volume 175, Issue 12, Page JC140, December 2022.
Short Life Expectancy No Deterrent to Cancer Screening for Some Physicians
Nearly a quarter of physicians do not believe that a patient’s life expectancy should be a metric for halting cancer screening, despite guidelines that recommend against routine cancer screening when life expectancy is less than 10 years. What’s more, less than half of physicians are convinced the overscreening is a major problem among older adults.
In older men, an invitation for comprehensive CV screening did not reduce death at 5.6 y
Annals of Internal Medicine, Ahead of Print.
Quaderno di assistenza sanitaria primaria per bambini e adolescenti: linee guida per la promozione della salute, la prevenzione e la gestione delle malattie dal periodo neonatale all’adolescenza (2022)
Non solo medicinali, in 1 farmacia su 3 pure vaccini o screening
Presentato il 5/o Rapporto di Cittadinanzattiva e Federfarma
Aids, Unicef: ogni giorno muoiono 301 bambini e adolescenti
Sono 850 i nuovi contagi nella fascia di età tra zero e 19 anni. Sono i dati diffusi in occasione della Giornata mondiale contro l’Aids
Prostate-Specific Antigen Screening Rates and Metastatic Prostate Cancer Incidence in the VHA
This cohort study assesses the association of prostate-specific antigen screening with incidence of metastatic prostate cancer in the Veterans Health Administration (VHA) from 2005 to 2019.
Artificial Intelligence in Breast Cancer Screening
This review examines the current FDA regulatory process for artificial intelligence products used in breast cancer screening and suggests system improvements.