Exercise Might Lower Heart Disease Risk in Part By Decreasing Stress in the Brain

Physical activity might reduce the risk of cardiovascular disease partly by decreasing activity in parts of the brain related to stress, a study in the Journal of the American College of Cardiology suggests. Researchers looked at data from more than 50 300 adults in Massachusetts who completed an exercise survey and more than 700 who underwent brain imaging. People who exercised more tended to have fewer cardiovascular disease events and lower activity in stress-related brain regions, the researchers reported.

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Giugno 2024

Correlation between uncertainty stress and depression among healthcare professionals in China: a nationwide cross-sectional survey

Objective
This study investigated the correlation between uncertainty stress (US) and depression among healthcare professionals (HCPs) in China.

Design, settings and participants
A cross-sectional online survey was conducted by recruiting HCPs from three provinces in China (central, eastern and western) through purposive sampling between 29 September 2022 and 18 January 2023. US was measured using the Life Stress Questionnaire and depression was measured using the Patient Health Questionnaire-9. In total, 2976 questionnaires were deemed valid.

Primary and secondary outcome
This study examined the prevalence of US and depression among HCPs in China; the correlating sociodemographic traits; and the correlation between US and depression.

Results
The prevalence of US and depression among HCPs in China was 26.54% (790 out of 2976) and 71.63% (2132 out of 2976). Binary logistic analysis revealed that individuals with graduate degrees (OR: 1.83; 95% CI 1.07 to 3.11; p

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Giugno 2024

The integrated stress response in pancreatic development, tissue homeostasis, and cancer

Present in all eukaryotic cells, the integrated stress response (ISR) is a highly coordinated signaling network that controls cellular behavior, metabolism and survival in response to diverse stresses. The ISR is initiated when any one of four stress sensing kinases (PERK, GCN2, PKR, HRI) becomes activated to phosphorylate the protein translation initiation factor eIF2α, shifting gene expression toward a comprehensive rewiring of cellular machinery to promote adaptation. While the ISR has been shown to play an important role in the homeostasis of multiple tissues, evidence suggests that it is particularly crucial for the development and ongoing health of the pancreas.

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Maggio 2024